VUNO's AI-based solution for Brain MRI Diagnostics

VUNO Med^®-DeepBrain™

A highly accurate and fast atrophy and WMH measurement AI solution
to assist diagnosis of neurodegenerative diseases

Qualified
Information

Provides volumetric data of 104 brain regions
with cortical thickness and White Matter Hyperintensity (WMH)

Parcellation

Cortical thickness

WMH

Enables atrophy analysis by providing normative percentile*,
longitudinal analysis, MTA score

(*compared to age/gender +/- 2 years)

Brain Region	*% of ICV (%)			% of ICV, **NP (%ile)
Brain Region	Left	Right	Total	Left	Right	Total
Temporal Lobe
Hippocampus	0.26	0.27	0.53	8.22	2.52	3.85
Amygdala	0.10	0.10	0.20	8.22	6.67	5.51
Entorhinal Cortex	0.09	0.07	0.16	5.74	<1	1.03
Parahippocampal Gyrus	0.14	0.11	0.25	55.09	7.68	25.21
Fusiform Gyrus	0.56	0.53	1.09	16.38	9.15	10.19
Temporal Pole	0.12	0.13	0.25	<1	8.37	1.09
Superior Temporal Gyrus	0.71	0.65	1.36	<1	<1	<1
Middle Temporal Gyrus	0.63	0.62	1.25	24.64	<1	3.64
Inferior Temporal Gyrus	0.65	0.55	1.20	46.26	3.15	14.41
Total Temporal Lobe	3.26	3.03	6.29	1.27	<1	<1
Ventricle
Lateral Ventricle	1.53	1.33	2.87	90.37	85.59	88.88
Inferior Lateral Ventricle	0.06	0.09	0.15	70.12	97.95	90.90
Total Ventricle	-	-	3.29	-	-	87.29

* % of ICV : Percentage of ICV | ** NP : Normative Percentiles

Accuracy

Demonstrated high accuracy of brain
regions & ICV (Intra-Cranial Volume)
segmentation

Whole Brain Segmentation Accuracy

Brain Area	Target Performance	Dice Similaraity Coefficien (95% CI)	Pass/Fail
T1 Whole Brain Regions	0.80	0.913 (0.891-0.936)	Pass
T2 WMH Region	0.80	0.939 (0.927-0.951)	Pass

ICV Segmentation Accuracy

Each ICV values of AD, MCI and CN populations provided by three solutions (VUNO, Product A and Product B) are compared with the True ICV values labelled by specialists. VUNO Med^®-DeepBrain™ demonstrated the highest consistency and smallest differences from the True ICV, when compared to the other two solutions.